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Phospho-APBB1(S347) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession O00213
Clone Names 4101010
Peptide ID 4101010
Additional Information
Gene ID 322
Other Names Amyloid beta A4 precursor protein-binding family B member 1, Protein Fe65, APBB1, FE65, RIR
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3024a was selected from the region of human Phospho-APBB1-S347. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name APBB1
Synonyms FE65, RIR
Function Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro- apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).
Cellular Location Cell membrane. Cytoplasm. Nucleus. Cell projection, growth cone. Nucleus speckle Note=Colocalizes with TSHZ3 in axonal growth cone (By similarity) In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP. Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus Nuclear translocation is under the regulation of APP. Colocalizes with TSHZ3 in the nucleus. Colocalizes with NEK6 at the nuclear speckles. Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity).
Tissue Location Highly expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease
Research Areas
Citations (0)

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APBB1 is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression.


1. Kinoshita, A., et al., J. Biol. Chem. 278(42):41182-41188 (2003). 2. Walsh, D.M., et al., Biochemistry 42(22):6664-6673 (2003). 3. Zhao, Q., et al., Biochemistry 42(12):3627-3634 (2003). 4. Hu, Q., et al., Hum. Mol. Genet. 11(4):465-475 (2002). 5. Bruni, P., et al., J. Biol. Chem. 277(38):35481-35488 (2002).

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$ 80.00
Cat# BP3024a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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