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Phospho-mouse IKKg(S375) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession O88522
Clone Names 4100207
Peptide ID 4100207
Additional Information
Gene ID 16151
Other Names NF-kappa-B essential modulator, NEMO, IkB kinase-associated protein 1, IKKAP1, mFIP-3, Inhibitor of nuclear factor kappa-B kinase subunit gamma, I-kappa-B kinase subunit gamma, IKK-gamma, IKKG, IkB kinase subunit gamma, NF-kappa-B essential modifier, Ikbkg, Nemo
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3129a was selected from the region of human Mouse Phospho-IKKg-S375. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ikbkg
Synonyms Nemo
Function Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B- mediated protection from cytokine toxicity. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
Cellular Location Cytoplasm. Nucleus
Research Areas
Citations (0)

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IKKg is a regulatory subunit part of the IKK-signalosome complex activation. It is also considered to be a mediator for TAX activation of NF-kappa-B. Additionally, this protein could be implicated in NF-kappa-B-mediated protection from cytokine toxicity.


J. Cereb. Blood Flow Metab. 25 (10), 1301-1311 (2005)J. Clin. Invest. 115 (4), 849-859 (2005)J. Biol. Chem. 279 (52), 54248-54257 (2004)Mol. Cells 18 (2), 200-206 (2004)Proc. Natl. Acad. Sci. U.S.A. 100 (3), 1203-1208 (2003)

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$ 80.00
Cat# BP3129a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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