|Other Names||ETS domain-containing protein Elk-1, ELK1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3424a was selected from the region of human Phospho-ELK1-T417. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element.|
|Tissue Location||Lung and testis.|
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Provided below are standard protocols that you may find useful for product applications.
ELK1 is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein is a nuclear target for the ras-raf-MAPK signaling cascade.
Salinas, S., et al., J. Cell Biol. 165(6):767-773 (2004).Yang, S.H., et al., Mol. Cell 12(1):63-74 (2003).Bebien, M., et al., Oncogene 22(12):1836-1847 (2003).Sharrocks, A.D., Biochem. Soc. Trans. 30(2):1-9 (2002).Murai, K., et al., Mol. Cell. Biol. 22(20):7083-7092 (2002).
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