|Other Names||ETS domain-containing protein Elk-1, ELK1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3424a was selected from the region of human Phospho-ELK1-T417. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).|
|Tissue Location||Lung and testis.|
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Provided below are standard protocols that you may find useful for product applications.
ELK1 is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein is a nuclear target for the ras-raf-MAPK signaling cascade.
Salinas, S., et al., J. Cell Biol. 165(6):767-773 (2004).Yang, S.H., et al., Mol. Cell 12(1):63-74 (2003).Bebien, M., et al., Oncogene 22(12):1836-1847 (2003).Sharrocks, A.D., Biochem. Soc. Trans. 30(2):1-9 (2002).Murai, K., et al., Mol. Cell. Biol. 22(20):7083-7092 (2002).
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