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Phospho-MAP4K4(S631) Antibody Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession O95819
Clone Names 110126
Peptide ID 110126
Additional Information
Gene ID 9448
Other Names Mitogen-activated protein kinase kinase kinase kinase 4, HPK/GCK-like kinase HGK, MAPK/ERK kinase kinase kinase 4, MEK kinase kinase 4, MEKKK 4, Nck-interacting kinase, MAP4K4, HGK, KIAA0687, NIK
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3426a was selected from the region of human Phospho-MAP4K4-pS631. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP4K4
Synonyms HGK, KIAA0687, NIK
Function Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.
Cellular Location Cytoplasm.
Tissue Location Appears to be ubiquitous. Expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta.
Research Areas
Citations (0)

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Background

M4K4, a member of the STE20 subfamily of Ser/Thr protein kinases, may play a role in the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain of the adapter proteins Nck. HGK binds, via its CNH regulatory domain, to the N-terminal region of SPG3A. Expression appears to be ubiquitous, expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain, and isoform 4 is predominant in the liver, skeletal muscle and placenta.

References

Wright, J.H., et al., Mol. Cell. Biol. 23(6):2068-2082 (2003).Yao, Z., et al., J. Biol. Chem. 274(4):2118-2125 (1999).Ishikawa, K., et al., DNA Res. 5(3):169-176 (1998).

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$ 120.00
Cat# BP3426a
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