|Other Names||GRB2-associated-binding protein 1, GRB2-associated binder 1, Growth factor receptor bound protein 2-associated protein 1, GAB1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP3599a was selected from the region of human Phospho-GAB1-pY259. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).|
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Provided below are standard protocols that you may find useful for product applications.
Gab1 is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis.
Guo A, et al. (2008) Proc Natl Acad Sci U S A 105, 692-7Rikova K, et al. (2007) Cell 131, 1190-203Goss VL, et al. (2006) Blood 107, 4888-97Wolf-Yadlin A, et al. (2006) Mol Syst Biol 2, 54Salomon AR, et al. (2003) Proc Natl Acad Sci U S A 100, 443-8
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