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Phospho-ABL-Y412 Antibody Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP3697a | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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Phospho-ABL-Y412 Antibody Blocking Peptide - Product info | |
| Primary Accession | P00519 |
| Calculated MW | 122873 Da |
Phospho-ABL-Y412 Antibody Blocking Peptide - Additional info | |
| Gene ID 25 | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
Phospho-ABL-Y412 Antibody Blocking Peptide - Protein Information | |
| Name ABL1 | |
| Synonyms ABL, JTK7 | |
| Function Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired Phosphorylates TP73, a primary regulator for this type of damage- induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin- associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1 | |
| Cellular Location Cytoplasm, cytoskeleton. Nucleus. Mitochondrion (By similarity). Note=Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress (By similarity) | |
| Tissue Location Widely expressed. | |
Phospho-ABL-Y412 Antibody Blocking Peptide - Related products
AP3502a: Phospho-ABL-pY283 Antibody
AP3503a: Phospho-ABL-pT754 Antibody
AP3011a: Phospho-ABL1-Y134 Antibody
AP3013a: Phospho-ABL1-Y245 Antibody
AP3014a: Phospho-ABL1-Y251 Antibody
AP3015a: Phospho-ABL1-Y272 Antibody
AP3016a: Phospho-ABL1-Y276 Antibody
AP3481a: Phospho-ABL-Y204 Antibody
AP7694a: ABL1 Antibody (N-term K219)
AP7694b: c ABL (ABL1) Antibody (C-term)
AP7694c: ABL1 Antibody (N-term H246)
AP7694d: ABL1 Antibody (Center)
BP3011a: Phospho-ABL1-Y134 Antibody Blocking Peptide
BP3013a: Phospho-ABL1-Y245 Antibody Blocking Peptide
BP3014a: Phospho-ABL1-Y251 Antibody Blocking Peptide
BP3015a: Phospho-ABL1-Y272 Antibody Blocking Peptide
BP3016a: Phospho-ABL1-Y276 Antibody Blocking Peptide
BP3481a: Phospho-ABL-Y204 Antibody Blocking Peptide
BP3502a: Phospho-ABL-pY283 Antibody Blocking Peptide
BP3503a: Phospho-ABL-pT754 Antibody Blocking Peptide
BP3697a: Phospho-ABL-Y412 Antibody Blocking Peptide
BP7694a: ABL1 Antibody (N-term K219) Blocking Peptide
BP7694b: ABL1 Antibody (C-term) Blocking Peptide
BP7694c: ABL1 Antibody (N-term H246) Blocking Peptide
Phospho-ABL-Y412 Antibody Blocking Peptide - Research Areas
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BACKGROUND
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.
REFERENCES
Fabbro, D., et al. Biochim. Biophys. Acta 1804(3):454-462(2010)Kim, M.J., et al. Cancer Genet. Cytogenet. 196(2):184-188(2010)Lewandowski, K., et al. Pol. Arch. Med. Wewn. 119(12):789-794(2009)Li, Y.N., et al. Zhonghua Nei Ke Za Zhi 48(6):481-484(2009)Wissing, J., et al. Mol. Cell Proteomics 6(3):537-547(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)
