|Other Names||Homeobox protein CDX-2, CDX-3, Caudal-type homeobox protein 2, CDX2, CDX3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.|
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Provided below are standard protocols that you may find useful for product applications.
The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear proteins that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. The proteins LMX1 (MIM 600298) and CDX3 are homeodomain proteins that bind an A/T-rich sequence in the insulin promoter and stimulate its transcription.
Benoit, Y.D., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 298 (4), G504-G517 (2010) Xie, Y., et al. Int. J. Oncol. 36(2):509-516(2010)Park do, Y., et al. Mod. Pathol. 23(1):54-61(2010)Lora, V., et al. Anticancer Res. 29(12):5033-5037(2009)Porjazova, E., et al. Akush Ginekol (Sofiia) 48(4):32-34(2009)
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