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Phospho-JMJD2A(Y547) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession O75164
Peptide ID 35078
Additional Information
Gene ID 9682
Other Names Lysine-specific demethylase 4A, 11411-, JmjC domain-containing histone demethylation protein 3A, Jumonji domain-containing protein 2A, KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KDM4A
Synonyms JHDM3A, JMJD2, JMJD2A, KIAA0677
Function Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00537, ECO:0000269|PubMed:15927959, ECO:0000269|PubMed:16024779}
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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JMJD2A is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.


Trojer, P., et al. J. Biol. Chem. 284(13):8395-8405(2009)Lee, J., et al. Nat. Struct. Mol. Biol. 15(1):109-111(2008)Katoh, Y., et al. Int. J. Mol. Med. 20(2):269-273(2007)

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$ 80.00
Cat# BP3726a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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Ordering Information

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