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Phospho-KIT(T718) Antibody Blocking peptide

Synthetic peptide

Product Information
Primary Accession P10721
Clone Names 111026082
Peptide ID 111026082
Additional Information
Gene ID 3815
Other Names Mast/stem cell growth factor receptor Kit, SCFR, Piebald trait protein, PBT, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, CD117, KIT, SCFR
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KIT
Synonyms SCFR
Function Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Cytoplasm. Note=Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head
Tissue Location Isoform 1 and isoform 2 are detected in spermatogonia and Leydig cells. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa (at protein level). Widely expressed. Detected in the hematopoietic system, the gastrointestinal system, in melanocytes and in germ cells
Research Areas
Citations (0)

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This gene encodes the human homolog of the proto-oncogenec-kit. C-kit was first identified as the cellular homolog of thefeline sarcoma viral oncogene v-kit. This protein is a type 3transmembrane receptor for MGF (mast cell growth factor, also knownas stem cell factor). Mutations in this gene are associated withgastrointestinal stromal tumors, mast cell disease, acutemyelogenous lukemia, and piebaldism. Multiple transcript variantsencoding different isoforms have been found for this gene.


Molderings, G.J., et al. Immunogenetics 62 (11-12), 721-727 (2010) :Cheng, M., et al. Circ. Res. 107(9):1083-1093(2010)Chi, P., et al. Nature 467(7317):849-853(2010)Rossi, S., et al. Am. J. Surg. Pathol. 34(10):1480-1491(2010)Chen, P., et al. World J. Gastroenterol. 16(33):4227-4232(2010)

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$ 80.00
Cat# BP3784g
(40 western blots)
Availability: In Stock
Bulk Size
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