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Phospho-rat TSC2(T1373) Blocking Peptide

Synthetic peptide

     
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  • CITATIONS
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Product Information
Primary Accession P49816
Other Accession NP_036812.2
Additional Information
Gene ID 24855
Other Names Tuberin, Tuberous sclerosis 2 protein homolog, Tsc2
Target/Specificity The synthetic peptide sequence is selected from aa 1366-1380 of RAT Tsc2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tsc2
Function In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.
Tissue Location CNS, uterus, heart, skeletal muscle, kidney and spleen
Research Areas
Citations (0)

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Background

acts as a tumor suppressor; may play a role in cell cycle regulation; acute phase response, and negative regulation of cell proliferation [RGD].

References

Larson, Y., et al. J. Biol. Chem. 285(32):24987-24998(2010)
Sajankila, S.P., et al. Mol. Cell. Biochem. 338 (1-2), 233-239 (2010) :
Inoue, H., et al. Biosci. Biotechnol. Biochem. 73(11):2488-2493(2009)
Di Nardo, A., et al. J. Neurosci. 29(18):5926-5937(2009)
Shiono, M., et al. Oncogene 27(52):6690-6697(2008)

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$ 120.00
Cat# BP3833a
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