|Other Names||Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta, PI3K-C2-beta, PtdIns-3-kinase C2 subunit beta, C2-PI3K, Phosphoinositide 3-kinase-C2-beta, PIK3C2B|
|Target/Specificity||The synthetic peptide sequence is selected from aa 215-230 of HUMAN PIK3C2B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.|
|Cellular Location||Microsome. Cell membrane. Cytoplasm, cytosol. Nucleus. Endoplasmic reticulum. Note=Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis|
|Tissue Location||Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.
Brown R.A.,et al.Biochem. Biophys. Res. Commun. 233:537-544(1997).
Arcaro A.,et al.J. Biol. Chem. 273:33082-33090(1998).
Gregory S.G.,et al.Nature 441:315-321(2006).
Arcaro A.,et al.Mol. Cell. Biol. 20:3817-3830(2000).
Wheeler M.,et al.Mol. Cell. Biol. 21:6660-6667(2001).
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