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SHOT1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession A0MZ66
Peptide ID 91113260
Additional Information
Gene ID 57698
Other Names Shootin-1, KIAA1598
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KIAA1598
Function Involved in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. Accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons (By similarity).
Cellular Location Cell projection, axon.
Research Areas
Citations (0)

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Background

SHOT1 involved in the generation of internal asymmetric signals required for neuronal polarization. SHOT1 acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. SHOT1 accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons.

References

Mangold, E., et al. Nat. Genet. 42(1):24-26(2010)Shimada, T., et al. J. Cell Biol. 181(5):817-829(2008)Larson, M.G., et al. BMC Med. Genet. 8 SUPPL 1, S5 (2007)

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$ 80.00
Cat# BP4725b
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