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TOIP1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q5JTV8 |
|---|
| Gene ID | 26092 |
|---|---|
| Other Names | Torsin-1A-interacting protein 1, Lamin-associated protein 1B, LAP1B, TOR1AIP1, LAP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TOR1AIP1 |
|---|---|
| Synonyms | LAP1 |
| Function | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. |
| Cellular Location | Nucleus inner membrane; Single-pass membrane protein |
| Tissue Location | Expressed in muscle, liver and kidney. [Isoform 4]: Expressed at higher levels than isoform 1 in lung, kidney and spleen (at protein level). Expressed at lower levels than isoform 1 in liver, brain and heart (at protein level). Similar levels of isoforms 1 and 4 are observed in ovary, testis and pancreas (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TOIP1 binds to A-and B-type lamins. TOIP1 possible role in membrane attachment and assembly of the nuclear lamina.
References
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Goodchild, R.E., et al. J. Cell Biol. 168(6):855-862(2005)
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