|Other Names||Torsin-1A-interacting protein 1, Lamin-associated protein 1B, LAP1B, TOR1AIP1, LAP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.|
|Cellular Location||Nucleus inner membrane; Single-pass membrane protein|
|Tissue Location||Expressed in muscle, liver and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
TOIP1 binds to A-and B-type lamins. TOIP1 possible role in membrane attachment and assembly of the nuclear lamina.
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Goodchild, R.E., et al. J. Cell Biol. 168(6):855-862(2005)
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