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ASMT Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P46597 |
|---|
| Gene ID | 438 |
|---|---|
| Other Names | Acetylserotonin O-methyltransferase, Hydroxyindole O-methyltransferase, HIOMT, ASMT |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ASMT |
|---|---|
| Function | [Isoform 1]: Catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). |
| Tissue Location | Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683) |
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Provided below are standard protocols that you may find useful for product applications.
Background
ASMT belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland.
References
Melke, J., et al. Mol. Psychiatry 13(1):90-98(2008)Toma, C., et al. Mol. Psychiatry 12(11):977-979(2007)Ross, M.T., et al. Nature 434(7031):325-337(2005)Itoh, M.T., et al. Horm. Metab. Res. 35(3):153-157(2003)
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