ATP6V1D Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y5K8 |
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Gene ID | 51382 |
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Other Names | V-type proton ATPase subunit D, V-ATPase subunit D, V-ATPase 28 kDa accessory protein, Vacuolar proton pump subunit D, ATP6V1D, ATP6M, VATD |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ATP6V1D |
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Synonyms | ATP6M, VATD |
Function | Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (PubMed:21844891). |
Cellular Location | Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin- coated vesicle membrane {ECO:0000250|UniProtKB:P39942}; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Note=Localizes to centrosome and the base of the cilium. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ATP6V1D encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d.
References
Smith, A.N., et al. J. Bioenerg. Biomembr. 40(4):371-380(2008)Morel, N. Biol. Cell 95(7):453-457(2003)Smith, A.N., et al. Mol. Cell 12(4):801-803(2003)Kawasaki-Nishi, S., et al. FEBS Lett. 545(1):76-85(2003)
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