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DDO Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q99489 |
|---|
| Gene ID | 8528 |
|---|---|
| Other Names | D-aspartate oxidase, DASOX, DDO, DDO |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DDO |
|---|---|
| Function | Selectively catalyzes the oxidative deamination of acidic amino acids (PubMed:9163533, PubMed:1991137, PubMed:20603179, PubMed:23391306, PubMed:25747990, PubMed:28560262, PubMed:28393897, PubMed:29292239, PubMed:32553892, PubMed:31914658, PubMed:28629864). Suppresses the level of D-aspartate in the brain, an amino acid that can act as an agonist for glutamate receptors (PubMed:28560262). Protects the organism from the toxicity of D-amino acids (By similarity). May also function in the intestine (By similarity). |
| Cellular Location | Peroxisome matrix. Cytoplasm, cytosol. Note=Active in the peroxisomal matrix [Isoform 3]: Peroxisome matrix |
| Tissue Location | Expressed in epithelial cells of the proximal nephron tubules in the renal cortex (at protein level) (PubMed:1991137, PubMed:12209855). In the brain, expressed in the frontal, temporal, and occipital lobes of the cortex, hippocampus, striatum, diencephalon, brainstem, cerebellum, spinal cord, plexus choroiderus and ependyma (at protein level) (PubMed:12209855, PubMed:28560262). Expression is increased in the prefrontal cortex of schizophrenic patients (PubMed:25689573). Levels are normal in the superior frontal gyrus of patients with Alzheimer's disease (PubMed:30822420) |
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Provided below are standard protocols that you may find useful for product applications.
Background
DDO is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction.
References
Jamra, R.A., et al. Psychiatr. Genet. 19 (1), 56 (2009) Mungall, A.J., et al. Nature 425(6960):805-811(2003)Zaar, K., et al. J. Comp. Neurol. 450(3):272-282(2002)
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