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DBF4B Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8NFT6 |
|---|
| Gene ID | 80174 |
|---|---|
| Other Names | Protein DBF4 homolog B, Activator of S phase kinase-like protein 1, ASK-like protein 1, Chiffon homolog B, Dbf4-related factor 1, DBF4B, ASKL1, DRF1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DBF4B |
|---|---|
| Synonyms | ASKL1, DRF1 |
| Function | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle. |
| Cellular Location | Nucleus. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction |
| Tissue Location | Widely expressed. Highly expressed in testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DBF4B encodes a regulator of the CDC7-like 1 protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and its expression is cell cycle-regulated. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
References
Tsuji, T., et al. Mol. Cell 32(6):862-869(2008)Yoshizawa-Sugata, N., et al. J. Biol. Chem. 280(13):13062-13070(2005)Montagnoli, A., et al. EMBO J. 21(12):3171-3181(2002)
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