|Other Names||DNA repair-scaffolding protein, Scaffolding protein involved in DNA repair, SPIDR, KIAA0146|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity.|
|Cellular Location||Nucleus. Note=Together with BLM, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment|
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Provided below are standard protocols that you may find useful for product applications.
Tang, B.S., et al. J. Virol. 79(10):6180-6193(2005)Lee, Y.W., et al. Mol. Med. 10 (1-6), 19-27 (2004)
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