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PTOR1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P85299
Peptide ID 91113020
Additional Information
Gene ID 55615
Other Names Proline-rich protein 5, Protein observed with Rictor-1, Protor-1, PRR5, PROTOR1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRR5
Synonyms PROTOR1
Function Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.
Tissue Location Most abundant in kidney and liver. Also highly expressed in brain, spleen, testis and placenta. Overexpressed in several colorectal tumors.
Research Areas
Citations (0)

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PTOR1 encodes a protein with a proline-rich domain. This protein is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. Rare read-through transcripts, containing exons from the ARHGAP8 gene which is located immediately downstream, led to the original description of PRR5 and ARHGAP8 as a single gene.


Woo, S.Y., et al. J. Biol. Chem. 282(35):25604-25612(2007)Pearce, L.R., et al. Biochem. J. 405(3):513-522(2007)Johnstone, C.N., et al. Genomics 85(3):338-351(2005)

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$ 80.00
Cat# BP4875b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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