|Other Names||Phospholipase DDHD2, 311-, DDHD domain-containing protein 2, KIAA0725p, SAM, WWE and DDHD domain-containing protein 1, DDHD2, KIAA0725, SAMWD1|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4- phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane.|
|Cellular Location||Cytoplasm, cytosol. Endoplasmic reticulum- Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note=Cycles between the Golgi apparatus and the cytosol DDHD2 recruitment to the Golgi/endoplasmic reticulum-Golgi intermediate compartment (ERGIC) is regulated by the levels of phosphoinositides, including PI(4)P|
|Tissue Location||Widely expressed (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
DDHD2 is phospholipase that hydrolyzes preferentially phosphatidic acid and phosphatidylethanolamine. DDHD2 may be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures.
Kwek, S.S., et al. Oncogene 28(17):1892-1903(2009)Nakajima, K., et al. J. Biol. Chem. 277(13):11329-11335(2002)
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