GLRX5 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q86SX6 |
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Gene ID | 51218 |
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Other Names | Glutaredoxin-related protein 5, mitochondrial, Monothiol glutaredoxin-5, GLRX5, C14orf87 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GLRX5 |
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Synonyms | C14orf87 |
Function | Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:20364084, PubMed:23615440). Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (PubMed:20364084, PubMed:23615440, PubMed:24334290). Required for normal regulation of hemoglobin synthesis by the iron- sulfur protein ACO1 (PubMed:20364084). |
Cellular Location | Mitochondrion matrix |
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Provided below are standard protocols that you may find useful for product applications.
Background
GLRX5 is monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. GLRX5 required for normal iron homeostasis. GLRX5 is required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1.
References
Bergmann, A.K., et al. Pediatr Blood Cancer 54(2):273-278(2010)Camaschella, C., et al. Blood 110(4):1353-1358(2007)Wingert, R.A., et al. Nature 436(7053):1035-1039(2005)
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