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PAAF1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BRP4 |
|---|
| Gene ID | 80227 |
|---|---|
| Other Names | Proteasomal ATPase-associated factor 1, Protein G-16, WD repeat-containing protein 71, PAAF1, WDR71 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PAAF1 |
|---|---|
| Synonyms | WDR71 |
| Function | Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation. |
| Tissue Location | Ubiquitously expressed, with highest levels in kidney, brain and testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PAAF1 inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency.
References
Lassot, I., et al. Mol. Cell 25(3):369-383(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) Ponnappan, S., et al. Int. J. Biochem. Cell Biol. 39(4):799-809(2007)
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