|Other Names||UBX domain-containing protein 6, UBX domain-containing protein 1, UBXN6, UBXD1, UBXDC2|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation.|
|Cellular Location||Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes at the centrosome both in interphase and during mitosis|
|Tissue Location||Enhanced expression in testis.|
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UBXN6 acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. UBXN6 is MDM2 stabilization leads to MDM2-dependent TP53 degradation.
Nagahama, M., et al. Biochem. Biophys. Res. Commun. 382(2):303-308(2009)Kern, M., et al. Biochem. Biophys. Res. Commun. 380(2):303-307(2009)Madsen, L., et al. Int. J. Biochem. Cell Biol. 40(12):2927-2942(2008)
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