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XBP1 Antibody (Center) Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP5088c | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
XBP1 Antibody (Center) Blocking Peptide - Product info | |
| Primary Accession | P17861 |
| Calculated MW | 28695 Da |
XBP1 Antibody (Center) Blocking Peptide - Additional info | |
| Gene ID 7494 | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
XBP1 Antibody (Center) Blocking Peptide - Protein Information | |
| Name XBP1 | |
| Synonyms TREB5, XBP2 | |
| Function Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE) Binds DNA preferably to the CRE-like element 5'- GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax- responsive element (TRE) of HTLV-I | |
| Cellular Location Nucleus. | |
XBP1 Antibody (Center) Blocking Peptide - Related products
AP12798b: XBP1 Antibody (C-term)
AP5088c: XBP1 Antibody (Center)
BP5088c: XBP1 Antibody (Center) Blocking Peptide
AT4549a: XBP1 Antibody (monoclonal) (M01)
XBP1 Antibody (Center) Blocking Peptide - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
XBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor.
REFERENCES
Navon, A., et al. FEBS Lett. 584(1):67-73(2010)Guan, D., et al. Mol. Carcinog. 49(1):68-74(2010)del Pozo, N., et al. Hum. Immunol. 70(11):950-952(2009)
