|Other Names||Ataxin-10, Brain protein E46 homolog, Spinocerebellar ataxia type 10 protein, ATXN10, SCA10|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.|
|Cellular Location||Cytoplasm, perinuclear region|
|Tissue Location||Expressed in the central nervous system.|
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ATXN10 encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of a pentanucleotide repeat in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10.
Li, Y., et al. Wei Sheng Wu Xue Bao 49(8):1081-1085(2009)Wardle, M., et al. J. Neurol. 256(3):343-348(2009)Almeida, T., et al. PLoS ONE 4 (2), E4553 (2009)
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