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ATXN10 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UBB4 |
|---|
| Gene ID | 25814 |
|---|---|
| Other Names | Ataxin-10, Brain protein E46 homolog, Spinocerebellar ataxia type 10 protein, ATXN10, SCA10 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ATXN10 |
|---|---|
| Synonyms | SCA10 |
| Function | Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. |
| Cellular Location | Cytoplasm, perinuclear region |
| Tissue Location | Expressed in the central nervous system. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ATXN10 encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of a pentanucleotide repeat in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10.
References
Li, Y., et al. Wei Sheng Wu Xue Bao 49(8):1081-1085(2009)Wardle, M., et al. J. Neurol. 256(3):343-348(2009)Almeida, T., et al. PLoS ONE 4 (2), E4553 (2009)
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