|Other Names||Roundabout homolog 4, Magic roundabout, ROBO4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).|
|Tissue Location||Specifically expressed in endothelial cells. Expressed at sites of angiogenesis in different tumor types|
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Provided below are standard protocols that you may find useful for product applications.
Roundabout 4 is receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. This protein may mediate the inhibition of primary endothelial cell migration by Slit proteins.
Jones, C.A., et al. Nat. Cell Biol. 11(11):1325-1331(2009)Sheldon, H., et al. FASEB J. 23(2):513-522(2009)Huang, L., et al. Mol. Vis. 15, 1057-1069 (2009)
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