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MIF Antibody (C-term) Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP5102b | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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MIF Antibody (C-term) Blocking Peptide - Product info | |
| Primary Accession | P14174 |
| Calculated MW | 12476 Da |
MIF Antibody (C-term) Blocking Peptide - Additional info | |
| Gene ID 4282 | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
MIF Antibody (C-term) Blocking Peptide - Protein Information | |
| Name MIF | |
| Synonyms GLIF, MMIF | |
| Function Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti- inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity | |
| Cellular Location Secreted. Cytoplasm. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non- classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens | |
MIF Antibody (C-term) Blocking Peptide - Related products
AP5102b: MIF Antibody (C-term)
BP5102b: MIF Antibody (C-term) Blocking Peptide
MIF Antibody (C-term) Blocking Peptide - Research Areas
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BACKGROUND
MIF encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways.
REFERENCES
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Palomino-Morales, R., et al. Clin. Exp. Rheumatol. 28(1):68-72(2010)Akcali, A., et al. J. Int. Med. Res. 38(1):69-77(2010)
