|Other Names||Monocyte to macrophage differentiation factor, Progestin and adipoQ receptor family member 11, Progestin and adipoQ receptor family member XI, MMD, PAQR11|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion.|
|Cellular Location||Late endosome membrane; Multi- pass membrane protein. Lysosome membrane; Multi-pass membrane protein|
|Tissue Location||Exhibits relatively ubiquitous expression with preferential expression in mature (in vitro differentiated) macrophages.|
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MMD is expressed by in vitro differentiated macrophages but not freshly isolated monocytes. Although sequence analysis identifies seven potential transmembrane domains, this protein has little homology to G-protein receptors and it has not been positively identified as a receptor. A suggested alternative function is that of an ion channel protein in maturing macrophages.
Tang, Y.T., et al. J. Mol. Evol. 61(3):372-380(2005)Rehli, M., et al. Biochem. Biophys. Res. Commun. 217(2):661-667(1995)
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