|Other Names||Monocyte to macrophage differentiation factor, Progestin and adipoQ receptor family member 11, Progestin and adipoQ receptor family member XI, MMD, PAQR11|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion.|
|Cellular Location||Late endosome membrane; Multi- pass membrane protein. Lysosome membrane; Multi-pass membrane protein|
|Tissue Location||Exhibits relatively ubiquitous expression with preferential expression in mature (in vitro differentiated) macrophages.|
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Provided below are standard protocols that you may find useful for product applications.
MMD is expressed by in vitro differentiated macrophages but not freshly isolated monocytes. Although sequence analysis identifies seven potential transmembrane domains, this protein has little homology to G-protein receptors and it has not been positively identified as a receptor. A suggested alternative function is that of an ion channel protein in maturing macrophages.
Tang, Y.T., et al. J. Mol. Evol. 61(3):372-380(2005)Rehli, M., et al. Biochem. Biophys. Res. Commun. 217(2):661-667(1995)
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