|Other Names||Protransforming growth factor alpha, Transforming growth factor alpha, TGF-alpha, EGF-like TGF, ETGF, TGF type 1, TGFA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.|
|Cellular Location||Transforming growth factor alpha: Secreted, extracellular space|
|Tissue Location||Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines|
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Provided below are standard protocols that you may find useful for product applications.
Transforming growth factors (TGFs) are biologically active polypeptides that reversibly confer the transformed phenotype on cultured cells. TGF-alpha shows about 40% sequence homology with epidermal growth factor (EGF; MIM 131530) and competes with EGF for binding to the EGF receptor (MIM 131550), stimulating its phosphorylation and producing a mitogenic response.
Han, S.W., et al. Cancer Sci. 101(3):793-799(2010)Trang, S.H., et al. Growth Factors 28(1):10-23(2010)Zhu, J., et al. Am. J. Med. Genet. A 152A (2), 291-298 (2010)
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