|Other Names||Myozenin-1, Calsarcin-2, Filamin-, actinin- and telethonin-binding protein, Protein FATZ, MYOZ1 (HGNC:13752)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.|
|Cellular Location||Nucleus. Cell projection, pseudopodium. Note=Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle|
|Tissue Location||Expressed primarily in skeletal muscle. Detected at lower levels in heart, prostate and pancreas|
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Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. This protein plays an important role in the modulation of calcineurin signaling, may play a role in myofibrillogenesis.
Aurino, S., et al. Acta Myol 27, 90-97 (2008) Posch, M.G., et al. Mol. Genet. Metab. 91(2):207-208(2007)Arola, A.M., et al. Mol. Genet. Metab. 90(4):435-440(2007)
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