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TM2D1 Blocking Peptide (N-term)

Synthetic peptide

Product Information
Primary Accession Q9BX74
Other Accession NP_114416.1
Additional Information
Gene ID 83941
Other Names TM2 domain-containing protein 1, Beta-amyloid-binding protein, hBBP, TM2D1, BBP
Target/Specificity The synthetic peptide sequence is selected from aa 59-72 of HUMAN TM2D1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TM2D1
Synonyms BBP
Function May participate in beta-amyloid-induced apoptosis via its interaction with beta-APP42.
Cellular Location Membrane; Multi-pass membrane protein
Tissue Location Widely expressed.
Research Areas
Citations (0)

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The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death.


Cam, J.A., et al. J. Biol. Chem. 279(28):29639-29646(2004)
Lee, Y., et al. J. Neurosci. Res. 73(2):255-259(2003)
Kirfel, G., et al. Eur. J. Cell Biol. 81(12):664-676(2002)
Kajkowski, E.M., et al. J. Biol. Chem. 276(22):18748-18756(2001)

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$ 80.00
$ 99.00
Cat# BP5380a
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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