|Other Names||TM2 domain-containing protein 1, Beta-amyloid-binding protein, hBBP, TM2D1, BBP|
|Target/Specificity||The synthetic peptide sequence is selected from aa 59-72 of HUMAN TM2D1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May participate in beta-amyloid-induced apoptosis via its interaction with beta-APP42.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death.
Cam, J.A., et al. J. Biol. Chem. 279(28):29639-29646(2004)
Lee, Y., et al. J. Neurosci. Res. 73(2):255-259(2003)
Kirfel, G., et al. Eur. J. Cell Biol. 81(12):664-676(2002)
Kajkowski, E.M., et al. J. Biol. Chem. 276(22):18748-18756(2001)
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