|Other Accession||Q8BZ00, NP_775924.1|
|Other Names||Sodium/hydrogen exchanger 9, Na(+)/H(+) exchanger 9, NHE-9, Solute carrier family 9 member 9, SLC9A9, NHE9|
|Target/Specificity||The synthetic peptide sequence is selected from aa 566-579 of HUMAN SLC9A9|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell.|
|Cellular Location||Late endosome membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitously expressed in all tissues tested. Expressed at highest levels in heart and skeletal muscle, followed by placenta, kidney, and liver. Expressed in the brain, in the medulla and spinal cord.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a sodium hydrogen exchanger that is a member of the solute carrier 9 protein family. The encoded protein localizes the to the late recycling endosomes and may play an important role in maintaining cation homeostasis. Defects in this gene are associated with attention-deficit/hyperactivity disorder.
Markunas, C.A., et al. Psychiatr. Genet. (2009) In press :
Vink, J.M., et al. Am. J. Hum. Genet. 84(3):367-379(2009)
Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1355-1358 (2008) :
Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008) :
Ng, D., et al. Int. J. Cancer 123(7):1610-1615(2008)
Levy, D., et al. BMC Med. Genet. 8 SUPPL 1, S3 (2007) :
Nakamura, N., et al. J. Biol. Chem. 280(2):1561-1572(2005)
de Silva, M.G., et al. J. Med. Genet. 40(10):733-740(2003)
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