|Other Names||Heterogeneous nuclear ribonucleoprotein A/B, hnRNP A/B, APOBEC1-binding protein 1, ABBP-1, HNRNPAB, ABBP1, HNRPAB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds single-stranded RNA. Has a high affinity for G- rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.|
|Cellular Location||Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to the subfamily of ubiquitouslyexpressed heterogeneous nuclear ribonucleoproteins (hnRNPs). ThehnRNPs are produced by RNA polymerase II and are components of theheterogeneous nuclear RNA (hnRNA) complexes. They are associatedwith pre-mRNAs in the nucleus and appear to influence pre-mRNAprocessing and other aspects of mRNA metabolism and transport.While all of the hnRNPs are present in the nucleus, some seem toshuttle between the nucleus and the cytoplasm. The hnRNP proteinshave distinct nucleic acid binding properties. The protein encodedby this gene, which binds to one of the components of themultiprotein editosome complex, has two repeats of quasi-RRM (RNArecognition motif) domains that bind to RNAs.
Jonson, L., et al. Mol. Cell Proteomics 6(5):798-811(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)Ong, S.E., et al. Nat. Methods 1(2):119-126(2004)
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