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SCD Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O00767 |
|---|---|
| Other Accession | NP_005054.3 |
| Clone Names | 90625064 |
| Gene ID | 6319 |
|---|---|
| Other Names | Acyl-CoA desaturase, Delta(9)-desaturase, Delta-9 desaturase, Fatty acid desaturase, Stearoyl-CoA desaturase, SCD |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SCD |
|---|---|
| Function | Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000269|PubMed:18765284, ECO:0000305} |
| Tissue Location | Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is aniron-containing enzyme that catalyzes a rate-limiting step in thesynthesis of unsaturated fatty acids. The principal product of SCDis oleic acid, which is formed by desaturation of stearic acid. Theratio of stearic acid to oleic acid has been implicated in theregulation of cell growth and differentiation through effects oncell membrane fluidity and signal transduction. Four SCD isoforms,Scd1 through Scd4, have been identified in mouse. In contrast, only2 SCD isoforms, SCD1 and SCD5 (MIM 608370), have been identified inhuman. SCD1 shares about 85% amino acid identity with all 4 mouseSCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5shares limited homology with the rodent SCDs and appears to beunique to primates (Zhang et al. (1999) [PubMed 10229681]; Wang etal., 2005 [PubMed 15907797]).
References
Collins, J.M., et al. J. Biol. Chem. 285(9):6044-6052(2010)Peter, A., et al. Diabetes 58(8):1757-1765(2009)Carmel, J.F., et al. J. Cell. Biochem. 106(4):608-617(2009)Zhou, Y.E., et al. Metab. Clin. Exp. 58(2):158-166(2009)
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