|Other Names||Aryl hydrocarbon receptor, Ah receptor, AhR, Class E basic helix-loop-helix protein 76, bHLHe76, AHR, BHLHE76|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.|
|Cellular Location||Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus|
|Tissue Location||Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
AHR is a ligand-activated transcription factorinvolved in the regulation of biological responses to planararomatic hydrocarbons. This receptor has been shown to regulatexenobiotic-metabolizing enzymes such as cytochrome P450. Itsligands included a variety of aromatic hydrocarbons. [provided byRefSeq].
Davila, S., et al. Genes Immun. (2010) In press :Kalthoff, S., et al. J. Biol. Chem. 285(9):5993-6002(2010)Hall, J.M., et al. Mol. Endocrinol. 24(2):359-369(2010)Schroeder, J.C., et al. Biochemistry 49(2):393-400(2010)
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