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AHR Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P35869
Other Accession NP_001612.1
Clone Names 90429015
Peptide ID 90429015
Additional Information
Gene ID 196
Other Names Aryl hydrocarbon receptor, Ah receptor, AhR, Class E basic helix-loop-helix protein 76, bHLHe76, AHR, BHLHE76
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AHR
Synonyms BHLHE76
Function Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.
Cellular Location Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus
Tissue Location Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle.
Research Areas
Citations (0)

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AHR is a ligand-activated transcription factorinvolved in the regulation of biological responses to planararomatic hydrocarbons. This receptor has been shown to regulatexenobiotic-metabolizing enzymes such as cytochrome P450. Itsligands included a variety of aromatic hydrocarbons. [provided byRefSeq].


Davila, S., et al. Genes Immun. (2010) In press :Kalthoff, S., et al. J. Biol. Chem. 285(9):5993-6002(2010)Hall, J.M., et al. Mol. Endocrinol. 24(2):359-369(2010)Schroeder, J.C., et al. Biochemistry 49(2):393-400(2010)

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$ 80.00
Cat# BP5533c
(40 western blots)
Availability: In Stock
Bulk Size
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