|Other Names||Aromatic-L-amino-acid decarboxylase, AADC, DOPA decarboxylase, DDC, DDC, AADC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.|
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Provided below are standard protocols that you may find useful for product applications.
This protein catalyzes the decarboxylation ofL-3,4-dihydroxyphenylalanine (DOPA) to dopamine,L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.Defects in this gene are the cause of aromatic L-amino-aciddecarboxylase deficiency (AADCD). AADCD deficiency is an inbornerror in neurotransmitter metabolism that leads to combinedserotonin and catecholamine deficiency.
Kokkinou, I., et al. J. Neuroimmunol. 216 (1-2), 51-58 (2009) :Meda, S.A., et al. Neuroimage (2009)Ishikawa, S., et al. J. Biol. Chem. 284(42):28832-28844(2009)Trevino, L.R., et al. Nat. Genet. 41(9):1001-1005(2009)
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