|Other Names||Ectonucleoside triphosphate diphosphohydrolase 7, NTPDase 7, 361-, Lysosomal apyrase-like protein 1, ENTPD7, LALP1|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Preferentially hydrolyzes nucleoside 5'-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP.|
|Cellular Location||Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localizes to intracellular vesicular compartments|
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The ENTPD7 belongs to the GDA1/CD39 NTPase family and the gene resides on chromosome 10q23-q24 and contains 12 exons and 11 introns covering a genomic region of approximately 46 kilobase pairs. The subcellular localization and enzymatic activity of ENTPD7 indicated that ENTPD7 is indeed an endo-apyrase with substrate preference for nucleoside triphosphates UTP, GTP, and CTP.
Deloukas, P., et al. Nature 429(6990):375-381(2004)Shi, J.D., et al. J. Biol. Chem. 276(20):17474-17478(2001)
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