|Other Names||DNA repair protein XRCC1, X-ray repair cross-complementing protein 1, XRCC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.|
|Cellular Location||Nucleus. Note=Accumulates at sites of DNA damage|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is involved in theefficient repair of DNA single-strand breaks formed by exposure toionizing radiation and alkylating agents. This protein interactswith DNA ligase III, polymerase beta and poly (ADP-ribose)polymerase to participate in the base excision repair pathway. Itmay play a role in DNA processing during meiogenesis andrecombination in germ cells. A rare microsatellite polymorphism inthis gene is associated with cancer in patients of varyingradiosensitivity.
Lamerdin, J.E., et al. Genomics 25(2):547-554(1995)Gyapay, G., et al. Nat. Genet. 7 (2 SPEC NO), 246-339 (1994) :Thompson, L.H., et al. Mol. Cell. Biol. 10(12):6160-6171(1990)Thompson, L.H., et al. Genomics 5(4):670-679(1989)
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