|Other Names||3-oxo-5-alpha-steroid 4-dehydrogenase 2, 5 alpha-SR2, SR type 2, Steroid 5-alpha-reductase 2, S5AR 2, Type II 5-alpha reductase, SRD5A2|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|
|Cellular Location||Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in high levels in the prostate and many other androgen-sensitive tissues|
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This gene encodes a microsomal protein expressed at highlevels in androgen-sensitive tissues such as the prostate. Theencoded protein is active at acidic pH and is sensitive to the4-azasteroid inhibitor finasteride. Deficiencies in this gene canresult in male pseudohermaphroditism, specifically pseudovaginalperineoscrotal hypospadias (PPSH).
Thigpen, A.E., et al. N. Engl. J. Med. 327(17):1216-1219(1992)Thigpen, A.E., et al. J. Clin. Invest. 90(3):799-809(1992)Labrie, F., et al. Endocrinology 131(3):1571-1573(1992)Andersson, S., et al. Nature 354(6349):159-161(1991)
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