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BDHA1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P08559 |
|---|---|
| Other Accession | NP_000275.1 |
| Clone Names | 90713270 |
| Gene ID | 5160 |
|---|---|
| Other Names | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, PDHE1-A type I, PDHA1, PHE1A |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PDHA1 |
|---|---|
| Synonyms | PHE1A |
| Function | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. |
| Cellular Location | Mitochondrion matrix. |
| Tissue Location | Ubiquitous. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The pyruvate dehydrogenase (PDH) complex is anuclear-encoded mitochondrial multienzyme complex that catalyzesthe overall conversion of pyruvate to acetyl-CoA and CO(2), andprovides the primary link between glycolysis and the tricarboxylicacid (TCA) cycle. The PDH complex is composed of multiple copies ofthree enzymatic components: pyruvate dehydrogenase (E1),dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase(E3). The E1 enzyme is a heterotetramer of two alpha and two betasubunits. This gene encodes the E1 alpha 1 subunit containing theE1 active site, and plays a key role in the function of the PDHcomplex.
References
Glushakova, L.G., et al. Mol. Genet. Metab. 98(3):289-299(2009)Joao Silva, M., et al. Eur. J. Pediatr. 168(1):17-22(2009)Boichard, A., et al. Mol. Genet. Metab. 93(3):323-330(2008)
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