|Other Names||Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, PDHE1-A type I, PDHA1, PHE1A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.|
|Cellular Location||Mitochondrion matrix.|
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Provided below are standard protocols that you may find useful for product applications.
The pyruvate dehydrogenase (PDH) complex is anuclear-encoded mitochondrial multienzyme complex that catalyzesthe overall conversion of pyruvate to acetyl-CoA and CO(2), andprovides the primary link between glycolysis and the tricarboxylicacid (TCA) cycle. The PDH complex is composed of multiple copies ofthree enzymatic components: pyruvate dehydrogenase (E1),dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase(E3). The E1 enzyme is a heterotetramer of two alpha and two betasubunits. This gene encodes the E1 alpha 1 subunit containing theE1 active site, and plays a key role in the function of the PDHcomplex.
Glushakova, L.G., et al. Mol. Genet. Metab. 98(3):289-299(2009)Joao Silva, M., et al. Eur. J. Pediatr. 168(1):17-22(2009)Boichard, A., et al. Mol. Genet. Metab. 93(3):323-330(2008)
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