|Other Names||Cytochrome c oxidase subunit 7C, mitochondrial, Cytochrome c oxidase polypeptide VIIc, COX7C|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.|
|Cellular Location||Mitochondrion inner membrane.|
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Cytochrome c oxidase (COX), the terminal component of themitochondrial respiratory chain, catalyzes the electron transferfrom reduced cytochrome c to oxygen. This component is aheteromeric complex consisting of 3 catalytic subunits encoded bymitochondrial genes and multiple structural subunits encoded bynuclear genes. The mitochondrially-encoded subunits function inelectron transfer, and the nuclear-encoded subunits may function inthe regulation and assembly of the complex. This nuclear geneencodes subunit VIIc, which shares 87% and 85% amino acid sequenceidentity with mouse and bovine COX VIIc, respectively, and is foundin all tissues. A pseudogene COX7CP1 has been found on chromosome13.
Sirchia, R., et al. Biol. Chem. 388(5):457-465(2007)Hofmann, S., et al. Cytogenet. Cell Genet. 83 (3-4), 226-227 (1998) Koga, Y., et al. Nucleic Acids Res. 18 (3), 684 (1990) :
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