UFM1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P61960 |
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Other Accession | NP_057701.1 |
Clone Names | 91102181 |
Gene ID | 51569 |
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Other Names | Ubiquitin-fold modifier 1, UFM1, C13orf20 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | UFM1 {ECO:0000303|PubMed:15071506, ECO:0000312|HGNC:HGNC:20597} |
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Function | Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer (PubMed:15071506, PubMed:20018847, PubMed:29868776, PubMed:27653677). The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847, PubMed:29868776, PubMed:27653677). Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (PubMed:32160526). Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription (PubMed:25219498). |
Cellular Location | Nucleus. Cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
UFM1 is a ubiquitin-like protein that is conjugated totarget proteins by E1-like activating enzyme UBA5 (UBE1DC1; MIM610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in amanner analogous to ubiquitylation (see UBE2M; MIM 603173).
References
Tatsumi, K., et al. J. Biol. Chem. 285(8):5417-5427(2010)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Sasakawa, H., et al. Biochem. Biophys. Res. Commun. 343(1):21-26(2006)Komatsu, M., et al. EMBO J. 23(9):1977-1986(2004)Dunham, A., et al. Nature 428(6982):522-528(2004)
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