|Other Names||Sia-alpha-2, 3-Gal-beta-1, 4-GlcNAc-R:alpha 2, 8-sialyltransferase, 2499-, Alpha-2, 8-sialyltransferase 8C, Alpha-2, 8-sialyltransferase III, ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sialyltransferase 3, Sialyltransferase 8C, SIAT8-C, Sialyltransferase St8Sia III, ST8SiaIII, ST8SIA3, SIAT8C|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alpha-2,8-linkages. Is active with alpha-2,3-linked, alpha-2,6-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. Displays preference for substrates with alpha-2,3-linked terminal sialic acid. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed in fetal and adult brain and fetal liver.|
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Provided below are standard protocols that you may find useful for product applications.
ST8SIA3 belongs to a family of sialyltransferases thatform sialyl-alpha-2,8-sialyl-R linkages at the nonreducing terminiof glycoconjugates (Lee et al., 1998 [PubMed 9826427]).
Fellay, J., et al. PLoS Genet. 5 (12), E1000791 (2009) :Kim, S.J., et al. Biochem. Biophys. Res. Commun. 344(4):1057-1064(2006)Angata, K., et al. J. Biol. Chem. 275(24):18594-18601(2000)Lee, Y.C., et al. Arch. Biochem. Biophys. 360(1):41-46(1998)Zeng, G., et al. Gene 187(1):131-134(1997)
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