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SIA8C Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O43173 |
|---|---|
| Other Accession | NP_056963.2 |
| Clone Names | 91119266 |
| Gene ID | 51046 |
|---|---|
| Other Names | Sia-alpha-2, 3-Gal-beta-1, 4-GlcNAc-R:alpha 2, 8-sialyltransferase, 2499-, Alpha-2, 8-sialyltransferase 8C, Alpha-2, 8-sialyltransferase III, ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sialyltransferase 3, Sialyltransferase 8C, SIAT8-C, Sialyltransferase St8Sia III, ST8SiaIII, ST8SIA3, SIAT8C |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ST8SIA3 (HGNC:14269) |
|---|---|
| Synonyms | SIAT8C |
| Function | Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8- linked sialic acid of an acceptor, such as N-linked oligosaccharides of glycoproteins and glycolipids through alpha-2,8-linkages (PubMed:9826427, PubMed:26192331, PubMed:10766765). Forms oligosialic and polysialic acid on various sialylated N-acetyllactosamine oligosaccharides of glycoproteins, including FETUB N-glycans, a2-HS- glycoprotein (AHSG) and alpha 2,3-sialylated glycosphingolipids, such as alpha 2,3-sialylparagloboside and ganglioside GM3 and to a lesser extent NCAM1 N-glycans (PubMed:9826427, PubMed:10766765). However, it is much more specific to N-linked oligosaccharides of glycoproteins than glycosphingolipids (By similarity). 2,3-sialylparagloboside serves as the best acceptor substrate among the glycolipids (By similarity). alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-6S-D-GlcNAc and monosialyl and disialyl N-acetyllactosamines are the best acceptor substrates among glycoproteins (PubMed:26192331, PubMed:10766765). May plays critical role in the striatum by mediating the formation of disialylated and trisialylated terminal glycotopes on N- and O-glycans of specific striatal proteins, regulating their distribution in lipid rafts, affecting their interaction with other binding partners, and subsequently modulating striatal functions (By similarity). |
| Cellular Location | Golgi apparatus membrane; Single-pass type II membrane protein |
| Tissue Location | Expressed in fetal and adult brain and fetal liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ST8SIA3 belongs to a family of sialyltransferases thatform sialyl-alpha-2,8-sialyl-R linkages at the nonreducing terminiof glycoconjugates (Lee et al., 1998 [PubMed 9826427]).
References
Fellay, J., et al. PLoS Genet. 5 (12), E1000791 (2009) :Kim, S.J., et al. Biochem. Biophys. Res. Commun. 344(4):1057-1064(2006)Angata, K., et al. J. Biol. Chem. 275(24):18594-18601(2000)Lee, Y.C., et al. Arch. Biochem. Biophys. 360(1):41-46(1998)Zeng, G., et al. Gene 187(1):131-134(1997)
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