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TTLL5 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6EMB2 |
|---|---|
| Other Accession | NP_055887.3 |
| Clone Names | 91119285 |
| Gene ID | 23093 |
|---|---|
| Other Names | Tubulin polyglutamylase TTLL5, 6---, SRC1 and TIF2-associated modulatory protein, Tubulin--tyrosine ligase-like protein 5, TTLL5, KIAA0998, STAMP |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TTLL5 (HGNC:19963) |
|---|---|
| Function | Polyglutamylase which modifies tubulin, generating polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent initiation step of the polyglutamylation reaction over the elongation step. Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity). Required for CCSAP localization to both polyglutamylated spindle and cilia microtubules (PubMed:22493317). Increases the effects of transcriptional coactivator NCOA2/TIF2 in glucocorticoid receptor- mediated repression and induction and in androgen receptor-mediated induction (PubMed:17116691). |
| Cellular Location | Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8CHB8}. Nucleus. Cytoplasm Note=Localized to the base of the connecting cilium between the basal body and the adjacent daughter centriole of the cilium. In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the nucleus in the presence of steroid {ECO:0000250|UniProtKB:Q8CHB8, ECO:0000269|PubMed:24791901} |
| Tissue Location | Expressed in the retina, found in the rod and cone photoreceptors (at protein level). Widely expressed with highest levels in heart and skeletal muscle and low levels in other tissues |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the tubulin tyrosine ligaselike protein family. This protein interacts with two glucocorticoidreceptor coactivators, transcriptional intermediary factor 2 andsteroid receptor coactivator 1. This protein may function as acoregulator of glucocorticoid receptor mediated gene induction andrepression. This protein may also function as an alpha tubulinpolyglutamylase.
References
van Dijk, J., et al. J. Biol. Chem. 283(7):3915-3922(2008)He, Y., et al. Mol. Cell. Biol. 27(4):1467-1485(2007)Janke, C., et al. Science 308(5729):1758-1762(2005)
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