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DI3L1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8TF46 |
|---|---|
| Other Accession | NP_001137160.1 |
| Clone Names | 91208191 |
| Gene ID | 115752 |
|---|---|
| Other Names | DIS3-like exonuclease 1, 3113-, DIS3L, DIS3L1, KIAA1955 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DIS3L |
|---|---|
| Synonyms | DIS3L1, KIAA1955 |
| Function | Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events (PubMed:20531386, PubMed:20531389, PubMed:37602378). In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA (PubMed:20531386, PubMed:20531389). |
| Cellular Location | Cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
DIS3L is a probable exonuclease. It has four isoforms.
References
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
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