|Other Names||Radial spoke head protein 4 homolog A, Radial spoke head-like protein 3, RSPH4A, RSHL3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules.|
|Cellular Location||Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium. Note=Radial spoke|
|Tissue Location||Expressed in trachea, lungs, and testes. Very strong expression is detected in nasal brushings|
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This gene encodes a protein that appears to be a componentthe radial spoke head, as determined by homology to similarproteins in the biflagellate alga Chlamydomonas reinhardtii andother ciliates. Radial spokes, which are regularly spaced alongcilia, sperm, and flagella axonemes, consist of a thin 'stalk' anda bulbous 'head' that form a signal transduction scaffold betweenthe central pair of microtubules and dynein. Mutations in this genecause primary ciliary dyskinesia 1, a disease arising fromdysmotility of motile cilia and sperm.
Castleman, V.H., et al. Am. J. Hum. Genet. 84(2):197-209(2009)
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