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RSPH4A Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q5TD94 |
|---|---|
| Other Accession | NP_001010892.1 |
| Clone Names | 91230106 |
| Gene ID | 345895 |
|---|---|
| Other Names | Radial spoke head protein 4 homolog A, Radial spoke head-like protein 3, RSPH4A, RSHL3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RSPH4A |
|---|---|
| Synonyms | RSHL3 |
| Function | Component of the axonemal radial spoke head which plays an important role in ciliary motility (PubMed:19200523). Essential for triplet radial spokes (RS1, RS2 and RS3) head assembly in the motile cilia (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium |
| Tissue Location | Expressed in trachea, lungs, and testes (PubMed:23993197). Very strong expression is detected in nasal brushings (PubMed:19200523). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that appears to be a componentthe radial spoke head, as determined by homology to similarproteins in the biflagellate alga Chlamydomonas reinhardtii andother ciliates. Radial spokes, which are regularly spaced alongcilia, sperm, and flagella axonemes, consist of a thin 'stalk' anda bulbous 'head' that form a signal transduction scaffold betweenthe central pair of microtubules and dynein. Mutations in this genecause primary ciliary dyskinesia 1, a disease arising fromdysmotility of motile cilia and sperm.
References
Castleman, V.H., et al. Am. J. Hum. Genet. 84(2):197-209(2009)
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