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ANKRD27 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q96NW4
Other Accession NP_115515.2
Clone Names 91102036
Peptide ID 91102036
Additional Information
Gene ID 84079
Other Names Ankyrin repeat domain-containing protein 27, VPS9 domain-containing protein, ANKRD27
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANKRD27
Function May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (PubMed:24856514).
Cellular Location Early endosome. Late endosome. Cytoplasmic vesicle membrane. Lysosome. Cell membrane. Melanosome {ECO:0000250|UniProtKB:Q3UMR0}. Note=Colocalizes with VAMP7 in transport vesicles in the shaft of hippoocampal neurons (By similarity). {ECO:0000250|UniProtKB:Q3UMR0}
Research Areas
Citations (0)

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ANKRD27 may be a Rab21 guanine exchange factor and regulate endosome dynamics (By similarity).


Burgo, A., et al. EMBO Rep. 10(10):1117-1124(2009)Wang, F., et al. Biochem. Biophys. Res. Commun. 372(1):162-167(2008)Zhang, X., et al. J. Cell. Sci. 119 (PT 6), 1053-1062 (2006) :Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)

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$ 80.00
Cat# BP5654b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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