|Other Names||Pituitary adenylate cyclase-activating polypeptide, PACAP, PACAP-related peptide, PRP-48, Pituitary adenylate cyclase-activating polypeptide 27, PACAP-27, PACAP27, Pituitary adenylate cyclase-activating polypeptide 38, PACAP-38, PACAP38, ADCYAP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.|
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Provided below are standard protocols that you may find useful for product applications.
ADCYAP1 is adenylate cyclase activating polypeptide1. Mediated by adenylate cyclase activating polypeptide 1receptors, this polypeptide stimulates adenylate cyclase andsubsequently increases the cAMP level in target cells. Adenylatecyclase activating polypeptide 1 is not only a hypophysiotropichormone, but also functions as a neurotransmitter andneuromodulator. In addition, it plays a role in paracrine andautocrine regulation of certain types of cells. This gene encodesthree different mature peptides, including two isotypes, a shorterform and a longer form.
Hosoya, M., et al. Biochim. Biophys. Acta 1129(2):199-206(1992)Ohkubo, S., et al. DNA Cell Biol. 11(1):21-30(1992)Kimura, C., et al. Biochem. Biophys. Res. Commun. 166(1):81-89(1990)
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