|Other Names||D-amino acid oxidase activator, Protein G72, DAOA, G72|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Seems to activate D-amino acid oxidase.|
|Cellular Location||Golgi apparatus.|
|Tissue Location||Expressed in amygdala, caudate nucleus, spinal cord and testis|
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Provided below are standard protocols that you may find useful for product applications.
DAOA is a protein that is an activator of theFAD-dependent enzyme D-amino acid oxidase, which degrades thegliotransmitter D-serine, a potent activator ofN-methyl-D-aspartate (NMDA) type glutamate receptors. Polymorphismsin this gene have been implicated in susceptibility toschizophrenia and bipolar affective disorder, possibly due todecreased levels of D-serine and decreased NMDA receptorfunctioning.
Schumacher, J., et al. Mol. Psychiatry 9(2):203-207(2004)Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :Hattori, E., et al. Am. J. Hum. Genet. 72(5):1131-1140(2003)Chumakov, I., et al. Proc. Natl. Acad. Sci. U.S.A. 99(21):13675-13680(2002)
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