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DAOA Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P59103 |
|---|---|
| Other Accession | NP_758958.3 |
| Clone Names | 90429096 |
| Gene ID | 267012 |
|---|---|
| Other Names | D-amino acid oxidase activator, Protein G72, DAOA, G72 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DAOA |
|---|---|
| Synonyms | G72 |
| Function | May suppress DAO (D-amino acid oxidase) and SOD1 activity and promote their degradation (PubMed:18544534, PubMed:20521334, PubMed:21679769, PubMed:30037290). Has conversely also been suggested to function as a DAO activator (PubMed:12364586, PubMed:24362575, PubMed:29114206). May stimulate the degradation of DDO (D-aspartate oxidase) (PubMed:37805834). May play a role in mitochondrial fission (PubMed:17684499). |
| Cellular Location | Cytoplasm, cytosol. Golgi apparatus. Mitochondrion. Note=May transiently pass through the Golgi apparatus |
| Tissue Location | Expressed in the amygdala and in astrocytes of the cortex (at protein level) (PubMed:18544534, PubMed:17684499, PubMed:12364586). Expressed in the caudate nucleus, spinal cord and testis (PubMed:12364586). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
DAOA is a protein that is an activator of theFAD-dependent enzyme D-amino acid oxidase, which degrades thegliotransmitter D-serine, a potent activator ofN-methyl-D-aspartate (NMDA) type glutamate receptors. Polymorphismsin this gene have been implicated in susceptibility toschizophrenia and bipolar affective disorder, possibly due todecreased levels of D-serine and decreased NMDA receptorfunctioning.
References
Schumacher, J., et al. Mol. Psychiatry 9(2):203-207(2004)Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :Hattori, E., et al. Am. J. Hum. Genet. 72(5):1131-1140(2003)Chumakov, I., et al. Proc. Natl. Acad. Sci. U.S.A. 99(21):13675-13680(2002)
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