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P2RX7 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q99572 |
|---|---|
| Other Accession | NP_002553.2 |
| Clone Names | 90504126 |
| Gene ID | 5027 |
|---|---|
| Other Names | P2X purinoceptor 7, P2X7, ATP receptor, P2Z receptor, Purinergic receptor, P2RX7 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | P2RX7 |
|---|---|
| Function | Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed with highest levels in brain and immune tissues. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
P2RX7 belongs to the family ofpurinoceptors for ATP. This receptor functions as a ligand-gatedion channel and is responsible for ATP-dependent lysis ofmacrophages through the formation of membrane pores permeable tolarge molecules. Activation of this nuclear receptor by ATP in thecytoplasm may be a mechanism by which cellular activity can becoupled to changes in gene expression.
References
Kim, M., et al. EMBO J. 20(22):6347-6358(2001)Gartland, A., et al. J. Bone Miner. Res. 16(5):846-856(2001)Gu, B.J., et al. J. Biol. Chem. 276(14):11135-11142(2001)Buell, G.N., et al. Recept. Channels 5(6):347-354(1998)Rassendren, F., et al. J. Biol. Chem. 272(9):5482-5486(1997)
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