|Other Names||P2X purinoceptor 7, P2X7, ATP receptor, P2Z receptor, Purinergic receptor, P2RX7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed with highest levels in brain and immune tissues.|
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Provided below are standard protocols that you may find useful for product applications.
P2RX7 belongs to the family ofpurinoceptors for ATP. This receptor functions as a ligand-gatedion channel and is responsible for ATP-dependent lysis ofmacrophages through the formation of membrane pores permeable tolarge molecules. Activation of this nuclear receptor by ATP in thecytoplasm may be a mechanism by which cellular activity can becoupled to changes in gene expression.
Kim, M., et al. EMBO J. 20(22):6347-6358(2001)Gartland, A., et al. J. Bone Miner. Res. 16(5):846-856(2001)Gu, B.J., et al. J. Biol. Chem. 276(14):11135-11142(2001)Buell, G.N., et al. Recept. Channels 5(6):347-354(1998)Rassendren, F., et al. J. Biol. Chem. 272(9):5482-5486(1997)
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